Psolusosides C1, C2, and D1, Novel Triterpene Hexaosides from the Sea CucumberPsolus fabricii (Psolidae, Dendrochirotida)

Abstract

Three new triterpene glycosides, psolusosides C1 (1), C2 (2) and D1 (3) have been isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk in the shallow waters of Onekotan Island (Kurile Islands). Five known glycosides: cladolosides B, M1, P2, isolated earlier from the sea cucumbers of genus Cladolabes and holotoxin A1 with 27- nor-25-oxo-holotoxin A1, isolated earlier from Apostichopus japonicus have also been found. The glycoside structures were elucidated by 2D NMR spectroscopy and HR mass-spectrometry. Compounds 1–3 possess hexasaccharide carbohydrate chains, identical for 1 and 2 and different in the third monosaccharide residue for 3. All the glycosides comprise holostane type aglycones with a 9(11)-double bond and a 16-keto-group and differ from each other in the side chains structures.