Affiliation:
1. The Jiangsu Provincial Platform for Conservation and Utilization of Agricultural Germplasm, Jiangsu Key laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu province and Chinese Academy of Sciences, Nanjing 210014, China
Abstract
A new quinolone alkaloid, 1-methyl-2-[( Z)-1-undecenyl]–4( 1H)-quinolone (1), together with two known quinolone alkaloids (2–3), and three known limonoids (4–6), were isolated from the fruits of Euodia rutaecarpa (Juss.) Benth.. Their chemical structure was determined by UV, MS, NMR and comparison with literatures. Bioassay results indicated that compound 1 had moderate cytotoxicity against tumor cell lines Lovo, MDA-MB-231 and HeLa with IC50 values of 6.72, 14.20 and 13.05 μM, respectively.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine