Anti-neutrophilic Inflammatory Secondary Metabolites from the Traditional Chinese Medicine, Tiankuizi-Reference-Cited by-同舟云学术

Anti-neutrophilic Inflammatory Secondary Metabolites from the Traditional Chinese Medicine, Tiankuizi

Published:2012-12 Issue:12 Volume:7 Page:1934578X1200701
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lee Chia-Lin¹²,Hwang Tsong-Long³,Peng Chieh-Yu¹²,Chen Chao-Jung⁴⁵,Chang Yuan-Shiun⁶,Wu Yang-Chang¹²⁷

Affiliation:

1. School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan

2. Natural Medicinal Products Research Center, China Medical University Hospital, Taichung 404, Taiwan

3. Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan

4. Graduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan

5. Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung 404, Taiwan

6. School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

7. Center for Molecular Medicine, China Medical University Hospital, Taichung 404, Taiwan

Abstract

Through bioassay-guided fractionation, thirteen compounds (1-13) were isolated from the dry root of Semiaquilegia adoxoides, known as Tiankuizi in traditional Chinese medicine (TCM). Among these, four benzoic acid derivatives (1, 2, 4, 5), one 4,6-dimethoxy-5-methyl-2 H-pyran-2-one (10) and one 1,2,3-propanetriol (13) were found for the first time in S. adoxoides. This is the first record of compound 10 from a natural source. 4-Hydroxybenzoic acid (1) and 3,4-dihyroxybenzoic acid (2) showed selective inhibition against elastase release and superoxide anion generation, with IC50 values of 3.20 and 6.21 μg/mL, respectively. Compound 1 had 7-fold better activity than the positive control against elastase release induced by human neutrophils. Overall, our studies demonstrated Tiankuizi (S. adoxoides) as a potential TCM and isolates 1 and 2 as promising lead compounds for neutrophilic inflammatory diseases.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200701221

Reference15 articles.

1. Constituents from the roots of Semiaquilegia adoxoides

2. A new nitroethylphenolic glycoside from Semiaquilegia adoxoides

3. Cyano- and nitro-containing compounds from the roots of Semiaquilegia adoxoides

4. Constituents from the Roots ofSemiaquilegia adoxoides

5. New diterpenoids fromSemiaquilegia adoxoides

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