Villarinol, a new Alkenoyloxyalkenol Derivative from the Endemic Philippine Rubiaceae species Villaria odorata-Reference-Cited by-同舟云学术

Villarinol, a new Alkenoyloxyalkenol Derivative from the Endemic Philippine Rubiaceae species Villaria odorata

Published:2012-06 Issue:6 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Macabeo Allan Patrick G.¹²,Avila Jalil A.¹,Alejandro Grecebio Jonathan D.³,Franzblau Scott G.⁴,Kouam Simeon F.⁵,Hussain Hidayat⁵,Krohn Karsten⁵

Affiliation:

1. Phytochemistry and Organic Synthesis Laboratory, Research Center for the Natural and Applied Sciences, University of Santo Tomas, Espana, Manila 1015, Philippines

2. Institut für Organische Chemie, Universität Regensburg, Universitätsstr. 31, 93053 Regensburg, Germany

3. Plant Sciences Laboratory, Research Center for the Natural Sciences, University of Santo Tomas, Espana, Manila 1015, Philippines

4. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., Chicago, Illinois 60612-7231, USA

5. Department of Chemistry, University of Paderborn, Warburger Str. 100, 33098 Paderborn, Germany

Abstract

Villarinol (1), a new alkenoyloxy alkenol metabolite, has been isolated from the dichloromethane extract of Villaria odorata, an endemic Rubiaceae Philippine plant, along with the known compounds stigmasterol and 4-hydroxybenzaldehyde. The structure of 1 was elucidated on the basis of spectroscopic and spectrometric studies. The extracts of V. odorata exhibited moderate inhibition against Mycobacterium tuberculosis H37Rv, based on the colorimetric microplate alamar blue assay.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700622

Reference15 articles.

1. Molecular phylogeny and taxonomic revision of the Philippine endemic Villaria Rolfe (Rubiaceae)

2. Indole alkaloids from the leaves of Philippine Alstonia scholaris

3. Highly oxygenated cyclohexene metabolites from Uvaria rufa

4. Cycloastragenol glycosides from Astragalus illyricus

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