A New Benzophenanthridine Alkaloid from Caloncoba Glauca-Reference-Cited by-同舟云学术

A New Benzophenanthridine Alkaloid from Caloncoba Glauca

Published:2017-03 Issue:3 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Agbo Jabar B.P.A.A.¹,Mpetga James D.S.²,Bikanga Raphael¹,Tchuenguem Roland T.³,Tsafack Rolande B.N.²,Awouafack Maurice D.²,Dzoyem Jean P.³,Ito Takuya⁴,Morita Hiroyuki⁴,Tane Pierre²

Affiliation:

1. Faculty of Science, University of Sciences and Technics of Masuku, P O Box 943, Franceville, Gabon

2. Department of Chemistry Faculty of Sciences, University of Dschang, P O Box 67, Dschang, Cameroon

3. Department of Biochemistry Faculty of Sciences, University of Dschang, P O Box 67, Dschang, Cameroon

4. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan

Abstract

Three alkaloids including a new one, N-formyldihydrochelerythrine (1), together with four other known compounds were isolated from the stem bark of Caloncoba glauca. The structure of the new compound was elucidated from spectroscopic and mass spectrometric evidence. This is the first report of alkaloids from the genus Caloncoba. Sesamin (4) [MIC = 256 μg/mL ( Candida albicans) and dihydrochelerythrine (2) [MIC = 32 ( C. albicans and C. parapsilosis), and 128 μg/mL ( C. krusei)] had moderate to weak antifungal activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200314

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2. Cytotoxic cycloartanes from the fruits of Caloncoba glauca

3. 30-Norfriedelane triterpenes from the stem bark ofCaloncoba glauca

4. Friedelane triterpenes from the stem bark of Caloncoba glauca

5. Lophocarpin and 21β-Hydroxylophocarpin, Two New 30-Norfriedelane Triterpenes fromCaloncoba Lophocarpa

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