Biotransformation of Mefenamic Acid by Cell Suspension Cultures of Solanum Mammosum-Reference-Cited by-同舟云学术

Biotransformation of Mefenamic Acid by Cell Suspension Cultures of Solanum Mammosum

Published:2008-02 Issue:2 Volume:3 Page:1934578X0800300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Surodjo Suzana¹,Salim Angela A.²,Suciati ¹²,Syahrani Achmad¹,Indrayanto Gunawan¹,Garson Mary J.²

Affiliation:

1. Plant Biotechnology Research Group, Faculty of Pharmacy, Airlangga University, Jl. Dharmawangsa Dalam, Surabaya, 60268, Indonesia

2. School of Molecular and Microbial Sciences, The University of Queensland, Brisbane QLD 4072, Australia

Abstract

Five biotransformation products, mefenamic acid-7- O-β-D-glucopyranosyl ester (2), mefenamic acid-7- O-β-D-(β-1,6- O-D-glucopyranosyl)-glucopyranosyl ester (3), mefenamic acid-7- O-β-D-(β-1,2- O-D-glucopyranosyl)-glucopyranosyl ester (4), mefenamic acid-7- O-β-D-(β-1,6- O-D-glucopyranosyl)-2-glucopyranose ester (5), and mefenamic acid-7- O-α-D-(β-1,6- O-D-glucopyranosyl)-2-glucopyranose ester (6) were isolated from cell suspension cultures of Solanum mammosum following administration of the therapeutic agent mefenamic acid (1). The structures of all new compounds were elucidated on the basis of their NMR and mass spectrometric data.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0800300231

Reference17 articles.

1. Biotransformation using plant cultured cells

2. 20-O-β-Glucopyranosyl Camptothecin from Mostuea brunonis: A Potential Camptothecin Pro-Drug with Improved Solubility

3. Structures of Mefenamic Acid Metabolites from Human Urine.