Three Sulfur-Containing Natural Products From Rubus Hirsutus Thunb-Reference-Cited by-同舟云学术

Three Sulfur-Containing Natural Products From Rubus Hirsutus Thunb

Published:2021-04 Issue:4 Volume:16 Page:1934578X2110113
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Lin Na¹²,Li Sihui²,Chen Xuexia²,Song Jianfeng³,Ge Yichao²,Wu Xiaodan⁴,Zhang Huifang⁵,Wu Bin²^ORCID

Affiliation:

1. Lishui Hospital of Traditional Chinese Medicine, Lishui, China

2. Ocean College, Zhejiang University, Zhoushan, China

3. Quzhou Institute for Food and Drug Control, Quzhou, China

4. Center of Analysis and Measurement, Zhejiang University, Hangzhou, China

5. Jinhua College of Vocation and Technology, Jinhua, China

Abstract

Chemical investigation of the leaves and stems of Rubus hirsutus Thunb has resulted in the isolation and characterization of a rare new tricyclic thienocyclopentapyran (1) and 2 known thiophenes, 5-(3-buten-1-ynul)−2,2’-bithiophene (2) and α-terthienyl (3). The structure of compound 1 was unambiguously determined by nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry and time-dependent density functional theory electronic circular dichroism calculations. The new compound 1 exhibited impressive antibiotic properties against methicillin resistant Staphylococcus aureus (MRSA), with an MIC value of around 1 µg/mL.

Funder

Lishui Science and Technology Bureau

Jinhua Science and Technology Project

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X211011383

Reference13 articles.

1. Natural Sulfur-Containing Compounds: An Alternative Therapeutic Strategy against Liver Fibrosis

2. Secondary sulfur metabolism in cellular signalling and oxidative stress responses

3. Phytoalexins from Brassicaceae: News from the front

4. Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example

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