Chemical Constituents of the Aerial Parts of Euphorbia Nematocypha

Author:

Xu Chen1,Jia Hai-Yang1,Zuo Bo1,Liao Zhi-Xin1,Ji Lan-Ju2,Sun Hong-Fa2,Wang Qi3

Affiliation:

1. School of Chemistry and Chemical engineering, Southeast University, Nanjing 211189, P.R. China

2. Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining, P.R. China

3. Key Laboratory of XinJiang Phytomedicine Resources, School of Pharmacy, Shihezi University, Shihezi 832002, P.R. China

Abstract

Chemical constituents of the dried aerial parts of Euphorbia nematocypha were investigated. A new oleanane triterpenoid, trans, trans-2′,4′-hexadienedioicacid-1′-β-amyrin ester (1), together with, β-amyrin (2), β-amyrin acetate (3), betulinic acid (4), ellagic acid (5), oleanolic acid (6), β-sitosterol (7), kaempferol (8), quercetin (9), lupeol (10) and pseudo-taraxasterol (11) were isolated from the methylene chloride extract. Their structures were elucidated on the basis of extensive spectroscopic (1D- & 2D-NMR) and ESI-MS analysis and comparison with data reported in the literature. The new isolated triterpenoid showed moderate cytotoxic activities against HeLa and MCF-7cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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