One New Terphenyl Glycoside From a Sponge-Derived Fungus Trichoderma reesei (HN-2016-018)

Author:

Rehman Saif Ur12,Wu Jing-Shuai13,Yang Lu-Jia13,Ting Shi13,Shao Chang-Lun13,Wang Chang-Yun13ORCID

Affiliation:

1. Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy; Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, Qingdao, People′s Republic of China

2. Department of Pharmacy, Faculty of Medical & Health Sciences, University of the Poonch, Rawalakot, Pakistan

3. Laboratory for Marine Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao, People′s Republic of China

Abstract

One new terphenyl glycoside (1), gliocladinin D, together with 4 known compounds (2-5) were isolated from the sponge-derived fungus Trichoderma reesei (HN-2016-018). The structure of the new compound was elucidated by the comprehensive spectroscopic analysis, including 1-dimensional and 2-dimensional nuclear magnetic resonance, and high-resolution electrospray ionization mass spectrometry. Compound 3 exhibited moderate Topo I inhibitory activity.

Funder

Taishan Scholars Program, China

Qingdao National Laboratory for Marine Science and Technology

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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