A New Chromene Derivative and a New Polyalcohol Isolated From the Fungus Xylaria sp. 111A Associated With Garcinia polyantha Leaves-Reference-Cited by-同舟云学术

A New Chromene Derivative and a New Polyalcohol Isolated From the Fungus Xylaria sp. 111A Associated With Garcinia polyantha Leaves

Published:2021-01 Issue:1 Volume:16 Page:1934578X2098733
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tegha Hycienth Fung¹²,Jouda Jean-Bosco³,Dzoyem Jean Paul⁴⁵⁶,Sema Denis Kehdinga¹²,Leutcha Bosco Peron¹²,Allémann Eric⁵⁶,Delie Florence⁵⁶,Shiono Yoshihito⁷,Sewald Norbert⁸,Lannang Alain Meli²³⁸^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, University of Maroua, Cameroon

2. Department of Chemistry, Higher Teachers’ Training College, University of Maroua, Cameroon

3. Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries, Ngaoundere, Cameroon

4. Department of Biochemistry, Faculty of Science, University of Dschang, Cameroon

5. School of Pharmaceutical Sciences, University of Geneva, Switzerland

6. Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Switzerland

7. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Japan

8. Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Germany

Abstract

From the crude extract of the plant-associated fungus Xylaria sp. collected in Cameroon, a new 2 H-chromene derivative, hexacycloxylariolone (1), and a new polyalcohol, xylatriol (2), were isolated, in addition to 3 known compounds, 2,3-furandiol (3), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5). Their chemical structures were established on the basis of the interpretation of spectroscopic data. Hexacycloxylariolone (1), 1,8-dimethoxynaphthalene (4), and 1-palmitoyl-rac-glycerol (5) showed antiproliferative activity by inhibiting the growth of Raw 264.7 and THP-1 cancer cell lines.

Funder

Alexander von Humboldt-Stiftung

Deutscher Akademischer Austauschdienst

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20987334

Reference21 articles.

1. Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum

2. Cytotoxic Compounds from the Leaves ofGarcinia polyantha

3. Antimalarial and cytotoxic constituents of Xylaria cf. cubensis PK108

4. Isopimarane diterpene glycosides, apoptosis inducers, obtained from fruiting bodies of the ascomycete Xylaria polymorpha

5. Cytotoxic 19,20-epoxycytochalasans from endophytic fungus Xylaria cf. curta

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