A New Cytotoxic Gymnomitrane Sesquiterpene from Ganoderma lucidum Fruiting Bodies-Reference-Cited by-同舟云学术

A New Cytotoxic Gymnomitrane Sesquiterpene from Ganoderma lucidum Fruiting Bodies

Published:2015-11 Issue:11 Volume:10 Page:1934578X1501001
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Binh Pham Thanh¹,Descoutures Dimitri²³,Dang Nguyen Hai¹,Dai Nguyen Nguyen Phuong⁴,Dat Nguyen Tien¹

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

2. University of Science and Technology of Hanoi, 18-Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam

3. Université Claude Bernard Lyon 1, Université de Lyon, 43 boulevard du 11 Novembre 1918, 69622 Villeurbanne, France

4. Department of Biology, University of Tay Nguyen, 567 Le Duan, Dac Lac City 630000, Vietnam

Abstract

A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3α,5α,9β,15-tetrol(1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501001125

Reference12 articles.

1. Herbal and Traditional Medicine

2. Secondary metabolites from Ganoderma

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4. Anti-diabetic effects of Ganoderma lucidum

5. Lingzhiols, Unprecedented Rotary Door-Shaped Meroterpenoids as Potent and Selective Inhibitors of p-Smad3 from Ganoderma lucidum

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