Lipid Metabolites from the Mushroom Meripilus giganteus

Abstract

The phytochemical investigation of the methanolic extract of the white rot fungus Meripilus giganteus resulted in the isolation and identification of compl mixtures of free fatty acids (1), monoacylglycerols (2), cerebrosides (3), ergosterol (4) and ergosterol peroxide (5). The structures of the isolated lip metabolites (1-5) were determined by chemical and spectroscopic methods. The antioxidant activity of the whole MeOH extract of the fungus was evaluat through in vitro model systems, such as 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide anion. In all two systems, the results indicated that the extra of the fungus showed the same free-radical-scavenging activity with SC50 data of 47.70 μg/mL, compared with the positive control quercetin (DPPH assa None of the isolated compounds (1-5) showed a significant activity. Compounds 2-4 were isolated from Meripilus giganteus for the first time.