The Anticancer Effects of Paeoniflorin and Its Underlying Mechanisms

Author:

Deng Li-Juan1,Lei Yu-He2,Chiu Tsz-Fung1,Qi Ming3,Gan Hua1,Zhang Ge2,Peng Zhi-Da4,Zhang Dong-Mei3,Chen Yan-Fen2,Chen Jia-Xu1

Affiliation:

1. Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, P.R. China

2. Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, P.R. China

3. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy, Jinan University, Guangzhou, P.R. China

4. Ji Chuang Health Technology Development (Guangzhou) Co., Ltd, P.R. China

Abstract

Paeoniflorin (PF) is an important pharmacological component of some Chinese traditional herbal formulas, such as Bai Shao, Chi Shao, and Dan Pi, which have been clinically used for centuries. Although many experimental studies have explored a wide range of pharmacological properties of PF, including anticancer, anti-inflammatory, antioxidant, immunoregulatory, and prevention of insulin resistance, there is no review to describe these reported effects systematically, especially the antitumor effect and the underlying mechanisms. In this review, we summarize the recent progress on the anticancer profiles both in vitro and in vivo of PF. Moreover, we highlight the integrated molecular mechanisms of PF and contemplate its future prospects as a potential anticancer drug.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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