Affiliation:
1. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2. College of Life Sciences, Zhejiang University, Hangzhou, 310058, China
3. National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
Abstract
Thirteen compounds were isolated from Artocarpus heterophyllus, including one new di-isoprenylated stilbene, (±)-artoheterin A (1), and twelve known isoprenylated phenolics, artocarbene (2), 3′,5′,2,4-tetrahydroxy-4′-(3-methyl-2-butenyl) stilbene (3), cudrastilbene (4), 3-(3-methyl-2-butenyl) luteolin (5), 5,7,2′,4′-tetrahydroxy-6-(3-methyl-2-butenyl) flavone (6), 6-(3-methyl-2-butenyl) apigenin (7), artochamin B (8), 5′-hydroxycudraflavone A (9), artonins A and B (10–11), heterophyllin (12), and 8-(3-methyl-2-butenyl)-6,7-dihydroxycoumarin (13). The structures of these compounds were identified by spectroscopic methods. All isolated compounds were screened for their inhibitory abilities against cathepsin K (CatK). Of them, compounds 1–4 and 8–13 were found to have suppression capabilities against CatK with IC50 values ranging from 1.9 to 73.7 μM.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine