Antimycobacterial Natural Products from Endophytes of the Medicinal Plant Aralia nudicaulis-Reference-Cited by-同舟云学术

Antimycobacterial Natural Products from Endophytes of the Medicinal Plant Aralia nudicaulis

Published:2015-10 Issue:10 Volume:10 Page:1934578X1501001
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Li Haoxin¹,Doucet Brandon¹,Flewelling Andrew J.¹,Jean Stephanie²³,Webster Duncan⁴,Robichaud Gilles A.²³,Johnson John A.¹,Gray Christopher A.¹⁵

Affiliation:

1. Department of Biology, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, Canada E2L 4L5

2. Department of Chemistry and Biochemistry, Universite de Moncton, Moncton, New Brunswick, Canada El A 3E9

3. Atlantic Cancer Research Institute, Moncton, New Brunswick, Canada E1C 8X3

4. Department of Medicine, Division of Infectious Diseases, Saint John Regional Hospital, Saint John, New Brunswick, Canada E2L 4L2

5. Department of Chemistry, University of New Brunswick, 30 Dineen Dr, Fredericton, NB, Canada E3B 5A3

Abstract

Antimycobacterial extracts of a Penicillium sp. (isolate HL4-159-41B) and a Coniothyrium sp. (isolate HL6-097-027B) isolated from the rhizomes of the Canadian medicinal plant Aralia nudicaulis were found to contain palitantin (1) and botrallin (2), craterellin C (3), mycosporulone (4), spiromassaritone (5), and massarigenin D (6) respectively. Bioassays against Mycobacterium tuberculosis H37Ra revealed that 1-4 possess moderate antimycobacterial activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501001003

Reference23 articles.

1. Canadian traditionally used medicinal plants: can they play a role in antituberculosis drug development?

2. Anti-mycobacterial triterpenes from the Canadian medicinal plant Alnus incana

3. The Canadian medicinal plant Heracleum maximum contains antimycobacterial diynes and furanocoumarins

4. Isolation and bioassay screening of medicinal plant endophytes from eastern Canada

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