Antibiotic Mycotoxins from an Endophytic Fusarium acuminatum Isolated from the Medicinal Plant Geum macrophyllum-Reference-Cited by-同舟云学术

Antibiotic Mycotoxins from an Endophytic Fusarium acuminatum Isolated from the Medicinal Plant Geum macrophyllum

Published:2018-10 Issue:10 Volume:13 Page:1934578X1801301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Clark Trevor N.¹,Carroll Madison²,Ellsworth Katelyn¹,Guerrette Roxann³⁴,Robichaud Gilles A.³⁴,Johnson John A.¹,Gray Christopher A.¹²

Affiliation:

1. Department of Biological Sciences, University of New Brunswick, 100 Tucker Park Rd, Saint John, NB, E2L 4L5, Canada

2. Department of Chemistry, University of New Brunswick, 30 Dineen Dr, Fredericton, NB, E3B 5A3, Canada

3. Department of Chemistry and Biochemistry, Université de Moncton, 18 Antonine-Maillet Ave, Moncton, NB, E1A 3E9, Canada

4. Atlantic Cancer Research Institute, 35 Providence Ave, Moncton, NB, E1C 8X3, Canada

Abstract

An extract of the endophytic fungus Fusarium acuminatum (TC2-084) isolated from the Canadian medicinal plant Geum macrophyllum exhibited significant antimycobacterial activity against Mycobacterium tuberculosis H37Ra when fermented in both malt extract and potato dextrose broths. However, significant differences observed in the NMR spectra of the respective extracts led us to further investigate both. Bioassay guided fractionation revealed that lateropyrone was solely responsible for the bioactivity observed when TC2-084 was fermented in malt extract broth, while the antimycobacterial activity of the extract derived from the isolate fermented in potato dextrose broth was augmented by the presence of enniatins B, B1, and B4 in addition to lateropyrone.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801301017

Reference16 articles.

1. Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes

2. Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites

3. Isolation and bioassay screening of medicinal plant endophytes from eastern Canada

4. Isolation of (–)–Avenaciolide as the Antifungal and Antimycobacterial Constituent of a Seimatosporium sp. Endophyte from the Medicinal Plant Hypericum perforatum

5. Pyrones. X. Lateropyrone, a new antibiotic from the fungus Fusariumlateritium Nees

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Endophytic fungi from the common walnut and their in vitro antagonistic activity against Ophiognomonia leptostyla;Biologia;2022-10-28

2. Root-associated endophytes isolated from juvenile Ulex europaeus L. (Fabaceae) plants colonizing rural areas in South-Central Chile;Plant and Soil;2022-02-17