Chemical Constituents of the Aerial Part of <i>Valeriana officinalis</i> var. <i>latifolia</i> Miq. With COX-2 Inhibitory Activity-Reference-Cited by-同舟云学术

Chemical Constituents of the Aerial Part of Valeriana officinalis var. latifolia Miq. With COX-2 Inhibitory Activity

Published:2022-02 Issue:2 Volume:17 Page:1934578X2210786
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ming Weikang¹²³,Zhang Zizhen¹³,Li Yanan¹³,Yi Ping¹³,Wang Miaomiao¹³,An Zhengbin¹³,Li Fei¹³,Gu Wei¹²³,Hao Xiaojiang¹²³⁴,Yuan Chunmao¹²³^ORCID

Affiliation:

1. State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People’s Republic of China

2. School of Pharmacuetical Sciences, Guizhou Medical University, Guiyang, People’s Republic of China

3. Key Laboratory of Chemistry for Natural Products of Guizhou Province, and Chinese Academy of Sciences, Guiyang, People’s Republic of China

4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China

Abstract

Twelve compounds, including a new iridoid (1) and 11 known compounds, were obtained from the aerial part of Valeriana officinalis var. latifolia Miq. Their structures were assigned by spectroscopic and mass spectrometric methods. All isolates were screened in vitro for cyclooxygenase-2 (COX-2) inhibitory activity. Two compounds (9 and 10) exhibited significant COX-2 inhibitory activity, with IC50 values ranging from 0.67 to 6.77 μM. The possible recognition mechanism between compound 9 and COX-2 was predicted by molecular docking analysis.

Funder

“Light of the West” Talent Cultivation Program of Chinese Academy of Sciences for Chunmao Yuan

National Natural Science Foundation of China

High-level Innovative Talents in Guizhou Province

the 13th batch of outstanding young scientific and technological talents in Guizhou Province

Science and Technology Project of Traditional Chinese Medicine and National Medicine of Guizhou Administration of Traditional Chinese Medicine

Natural Science and Technology Foundation of Guizhou Province

Guizhou Provincial Engineering Research Center for Natural Drugs, Guizhou Medical University

Science and Technology Plan of Guizhou Province

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X221078628

Reference19 articles.

1. Biomedically relevant chemical constituents of Valeriana officinalis

2. Iridoids and Sesquiterpenoids from the Roots of Valeriana officinalis

3. Lignans Isolated from Valerian: Identification and Characterization of a New Olivil Derivative with Partial Agonistic Activity at A1 Adenosine Receptors

4. Terpenoids from the Roots and Rhizomes of Nardostachys chinensis

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