Synthesis of Ester-Linked Paclitaxel–Glycoside Conjugate and Its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab-Reference-Cited by-同舟云学术

Synthesis of Ester-Linked Paclitaxel–Glycoside Conjugate and Its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab

Published:2021-01 Issue:1 Volume:16 Page:1934578X2095365
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Fujitaka Yuya¹,Hamada Hiroki¹^ORCID,Hamada Hatsuyuki²,Ishihara Kohji¹,Iwaki Takafumi³,Shimoda Kei⁴^ORCID,Kiriake Yuya⁵,Saikawa Tomohiro⁶

Affiliation:

1. Department of Life Science, Faculty of Science, Okayama University of Science, Japan

2. National Institute of Fitness and Sports in Kanoya, Shiromizu-cho, Kagoshima, Japan

3. Department of Biophysics, Faculty of Medicine, Oita University, Hasama-machi, Japan

4. Department of Biomedical Chemistry, Faculty of Medicine, Oita University, Hasama-machi, Japan

5. Faculty of Medicine and Health Sciences, Yamaguchi University, Minamikogushi, Ube-shi, Japan

6. Department of Nursing, Junshin Gakuen University, Tikushigaoka, Fukuoka, Japan

Abstract

Synthesis of the ester-linked glucoside conjugate of paclitaxel, 7-propionylpaclitaxel 3″- O-β-d-glucopyranoside, was carried out by chemoenzymatic procedures. The encapsulation efficiency (EE) values for hybrid-bio-nanocapsules of the compound were much improved in comparison with those of paclitaxel. The hybrid-bio-nanocapsules targeted with trastuzumab, which contained 7-propionylpaclitaxel 3″- O-β-d-glucopyranoside, showed high anticancer activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20953654

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