A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest [1a]-Reference-Cited by-同舟云学术

A Synthetic Butenolide Diterpene is now a Natural Product Isolated from Metaporana sericosepala, a Plant from the Madagascar Dry Forest [1a]

Published:2015-09 Issue:9 Volume:10 Page:1934578X1501000
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Presley Christopher C.¹,Rakotondraibe L. Harinantenaina¹²,Brodie Peggy J.¹,Callmander Martin W.³,Randrianaivo Richard⁴,Rasamison Vincent E.⁵,Rakotobe Etienne⁵,Kingston David G. I.¹

Affiliation:

1. Department of Chemistry, M/C 0212, Virginia Tech, Blacksburg, Virginia 24061-0212, USA

2. College of Pharmacy, Division of Medicinal Chemistry and Pharmacognosy, The Ohio State University, Columbus, OH 43210, USA

3. Missouri Botanical Garden, P.O. Box 299, St. Louis, Missouri 63166-0299, USA

4. Missouri Botanical Garden, B.P 3391, Antananarivo 101, Madagascar

5. Centre National d'Application des Recherches Pharmaceutiques, B.P 702, Antananarivo 101, Madagascar

Abstract

Antiproliferative bioassay-guided fractionation of the ethanolic extract of the endemic Madagascan plant Metaporana sericosepala led to the first natural product isolation of a butenolide diterpene, which was synthesized during an anti-inflammatory study in 1988. The structure of the compound was elucidated as 3-homofarnesyl-4-hydroxybutenolide (1) by analysis of its spectroscopic data, including 1D- and 2D-NMR data and chemical evidence. The once synthetic compound can now also be considered as a natural product. Compound 1 had modest antiproliferative activity towards the A2780 ovarian cancer cell line with an IC50 value of 8 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1501000904

Reference14 articles.

1. Antiproliferative compounds from Ocotea macrocarpa from the Madagascar dry forest

2. Regioselective oxidation of 3-alkylfurans to 3-alkyl-4-hydroxybutenolides

3. Structures and Potential Antitumor Activity of Sesterterpenes from the Marine Sponge Hyrtios communis

4. New Luffariellolide Derivatives from the Indonesian Sponge Acanthodendrilla sp.

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Therapeutic Perspective of Vitamin C and Its Derivatives;Antioxidants;2019-07-26