Methyl-β-D-glucopyranoside From <i>Scabiosa comosa</i> as a Quorum-Sensing Inhibitor-Reference-Cited by-同舟云学术

Methyl-β-D-glucopyranoside From Scabiosa comosa as a Quorum-Sensing Inhibitor

Published:2022-11 Issue:11 Volume:17 Page:1934578X2211399
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Davaapurev Bekh-Ochir¹,Fukumoto Atsushi²,Bolortuya Byambajav¹,Boldbaatar Delgerbat¹^ORCID,Maehata Yoshino²,Iizaka Yohei²,Kato Fumio²,Batkhuu Javzan¹,Anzai Yojiro²^ORCID

Affiliation:

1. School of Engineering and Applied Sciences, National University of Mongolia, Ulaanbaatar, Mongolia

2. Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba, Japan

Abstract

Quorum sensing (QS) is an important microbial signaling system that controls the expression of many virulence genes. Combination treatment with QS inhibitors and antibiotics may be the new treatment option for infectious diseases in the future. Therefore, there is an increasing need to discover anti-QS compounds to prevent antimicrobial resistance. We isolated methyl-β-D-glucopyranoside from Scabiosa comosa and found that it exerts an anti-QS activity against Chromobacterium violaceum CV026 without exhibiting any antimicrobial activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X221139972

Reference18 articles.

1. Effects of extracts from Italian medicinal plants on planktonic growth, biofilm formation and adherence of methicillin-resistant Staphylococcus aureus

2. Synergistic antibacterial efficacy of early combination treatment with tobramycin and quorum-sensing inhibitors against Pseudomonas aeruginosa in an intraperitoneal foreign-body infection mouse model

3. Quorum sensing and Chromobacterium violaceum: exploitation of violacein production and inhibition for the detection of N-acylhomoserine lactones

4. Quantification and antioxidant and anti-HCV activities of the constituents from the inflorescences ofScabiosa comosaandS. tschilliensis