Two New Naphthoquinone Derivatives from the Stem Bark of Callicarpa Maingayi

Abstract

Two new naphthoquinones designated as 3α-hydroxy-2-(2-hydroxypropan-2-yl)-9α-methoxy-2,3,3α,9α-tetra-hydronaphtho[2,3-b]furan-4,9-dione (callicarpa-quinone A, 1) and 5-hydroxy-2-(2-hydroxypropan-2-yl)naphtho[2,3-b]furan-4,9-dione (callicarpaquinone B, 2) were isolated from the chloroform fraction of Callicarpa maingayi. Three other known compounds, identified as avicequinone-C (3), wodeshiol (4) and paulownin (5), were reported for the first time from this species. The structure elucidation of compounds was established by comprehensive 1D and 2D NMR spectroscopic analyses as well as EIMS, UV and IR spectral data. Compounds 1 and 2 were tested in vitro for their cytotoxic activity against human breast cancer MCF-7cells. Compound 2 exhibited strong cytotoxic activity with an IC50 value of 1.9 ± 0.2 μM, while 1 showed moderate activity with an IC50 value of 25.0 ± 4.3 μM.