A New Immunosuppressive Pregnane Glycoside and Two Known Analogues from Epigynum cochinchinensis-Reference-Cited by-同舟云学术

A New Immunosuppressive Pregnane Glycoside and Two Known Analogues from Epigynum cochinchinensis

Published:2018-06 Issue:6 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Shao Yuting¹,Zhao Yan²,Zhang Hong²,Jiang Mengjun¹,Khan Afsar³,Zhao Tianrui¹,Zhou Zhihong⁴,Cheng Guiguang¹,Cao Jianxin¹

Affiliation:

1. Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, People's Republic of China

2. First People's Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650032, People's Republic of China

3. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad-22060, Pakistan

4. Yunnan Key Laboratory of Dai and Yi Medicines, Yunnan University of TCM, Kunming, 650500, People's Republic of China

Abstract

Phytochemical investigation of the ethyl acetate soluble fraction from the leaves of Epigynum cochinchinensis led to the isolation of one new C21 pregnane glycoside, epigycoside C (1), along with two known analogues epigycoside A (2) and epigynoside G (3). Their structures were elucidated on the basis of extensive spectroscopic techniques. The in vitro immunosuppressive activity of compound 1 was evaluated against concanavalin A (Con A)- and lipopolysaccharides (LPS)-stimulated proliferation of mice splenocytes. Compound 1 displayed significant immunosuppressive activities in a dose-dependent manner.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300604

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