Bioactive Components of Fissistigma cupreonitens-Reference-Cited by-同舟云学术

Bioactive Components of Fissistigma cupreonitens

Published:2018-06 Issue:6 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Chen I-Hsiao¹,Yang Ming-Yi²,Juang Shin-Hun³,Lee Chia-Lin⁴⁵,Thang Tran-Dinh⁶,El-Shazly Mohamed⁷⁸,Lan Yu-Hsuan²

Affiliation:

1. Department of Medical Laboratory Science, I Shou University, Kaohsiung 82445, Taiwan

2. School of Pharmacy, China Medical University, Taichung 40402, Taiwan

3. Department of Pharmacy and Master Program, Tajen University, Pingtung 90741, Taiwan

4. Department of Cosmeceutics, China Medical University, Taichung 40402, Taiwan

5. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, Taiwan

6. Department of Chemistry, Vinh University, Vinh City, Vietnam

7. Department of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, Ain-Shams University, Organization of African Unity Street, Abassia, Cairo 11566, Egypt

8. Department of Pharmaceutical Biology, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo 11432, Egypt

Abstract

Phytochemical investigation of Fissistigma cupreonitens (Annonaceae) led to the isolation of 34 compounds. The chemical structures of all compounds were determined by spectroscopic methods. Among the isolates, compounds 20–27 and 31–34 were reported from this genus for the first time. From the results of the cytotoxicity assay against three human cancer cell lines (NCI-H226, NPC-TW01, and Jurkat E6–1), oxoaporphine compounds oxoxylopine (1), oxocrebanine (3), kuafumine (4) and lysicamine (5), and the flavonoid adunctin E (26) displayed significant cytotoxicity against NCI-H226 cell line, with IC50 values of 8.45, 8.10, 8.54, 12.83 and 12.00 μM, respectively, in comparison with the standard drug, cisplatin with IC50 of 13.37 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300607

Reference59 articles.

1. Lung Cancer Risk in Females Due to Exposures to PM2.5 in Taiwan

2. Non-viral environmental risk factors for nasopharyngeal carcinoma: A systematic review

3. The effects of air pollutants on the mortality rate of lung cancer and leukemia

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