A New Prenylated Isoflavonoid From Limonium leptophyllum-Reference-Cited by-同舟云学术

A New Prenylated Isoflavonoid From Limonium leptophyllum

Published:2019-05 Issue:5 Volume:14 Page:1934578X1984413
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Dizamatova Asset¹,Zhumanova Kamila¹,Zhusupova Galiya E.¹,Zhussupova Aizhan I.¹,Srivedavyasasri Radhakrishnan²,Ibrahim Mohamed A.²³,Ross Samir A.²⁴

Affiliation:

1. Faculty of Chemistry and Chemical Technology, Al-Farabi Kazakh National University, Almaty, Republic of Kazakhstan

2. National Center for Natural Products Research, University of Mississippi, USA

3. Department of Chemistry of Natural Compounds, National Research Center, Cairo, Egypt

4. Department of BioMolecular Sciences, Division of Pharmacognosy, School of Pharmacy, University of Mississippi, USA

Abstract

Phytochemical investigation of methanolic extract of Limonium leptophyllum (Plumbaginaceae), led to the isolation of 1 new isoflavonoid with a rare 5-membered dihydrofuran ring (1, leptoisoflavone A) and 8 known compounds. The known isolated compounds were identified as euchrenone b9 (2), auriculasin (3), kaempferol (4), avicularoside (5), myricetin-3-arabinoside (6), trans-N-feruloyltyramine (7), trans-N-caffeoyltyramine (8), and β-sitosterol (9). The crude methanolic extract exhibited moderate activity toward endocannabinoid receptors. Auriculasin (3) showed activity toward cannabinoid receptor type 1 (86.7% displacement with IC50 8.92 μM).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X19844137

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