Phorbol Esters with Wnt Signal-Augmenting Effects Isolated from Excoecaria Indica-Reference-Cited by-同舟云学术

Phorbol Esters with Wnt Signal-Augmenting Effects Isolated from Excoecaria Indica

Published:2012-04 Issue:4 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yamaguchi Tatsuhiro¹,Toume Kazufumi¹,Arai Midori A.¹,Ahmed Firoj²,Sadhu Samir K.³,Ishibashi Masami¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

2. Department of Pharmacy, Jagannath University, Dhaka 1100, Bangladesh

3. Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh

Abstract

A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 – 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700414

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2. WNT and β-catenin signalling: diseases and therapies

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5. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

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