Phorbol Esters with Wnt Signal-Augmenting Effects Isolated from Excoecaria Indica

Author:

Yamaguchi Tatsuhiro1,Toume Kazufumi1,Arai Midori A.1,Ahmed Firoj2,Sadhu Samir K.3,Ishibashi Masami1

Affiliation:

1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan

2. Department of Pharmacy, Jagannath University, Dhaka 1100, Bangladesh

3. Pharmacy Discipline, Life Science School, Khulna University, Khulna 9208, Bangladesh

Abstract

A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 – 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. 10.1271/kagakutoseibutsu.52.541;KAGAKU TO SEIBUTSU;2014

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