Unusual 2(1H)-Pyrazinones Isolated from a Culture of a Brazilian Marine-Derived Streptomyces sp-Reference-Cited by-同舟云学术

Unusual 2(1H)-Pyrazinones Isolated from a Culture of a Brazilian Marine-Derived Streptomyces sp

Published:2014-09 Issue:9 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Thomasi Sérgio S.¹,Granato Ana C.²,Romano Luis H.³,Dhooghe Liene⁴,do Nascimento Eduardo S. P.¹,Badino Alberto C.³,da Silva Maria F. G. F.¹,Ferreira Antonio G.¹,Venâncio Tiago¹

Affiliation:

1. Departamento de Química, Universidade Federal de São Carlos, CP 676, CEP 13565–905, São Carlos, SP, Brazil

2. Departamento de Engenharia Química, Universidade Federal do Triângulo Mineiro, Av. Frei Paulino, 30 - Bairro Abadia, CEP 38025–180, Uberaba, MG, Brazil

3. Departamento de Engenharia Química, Universidade Federal de São Carlos, CP 676, CEP 13565–905, São Carlos, SP, Brazil

4. University of Antwerp, Middelheimlann 1, 2020, Antwerp, Belgium

Abstract

Four new secondary metabolites, giovaninones A-D (1–4), were isolated from an ethyl acetate extract of a culture of a marine-derived Streptomyces strain designated SS99BA-2. Chemical analysis was completely conducted in a coupled automated LC-SPE system with the use of a cryogenic NMR probehead and HRMS. The application of this system to identify, purify and elucidate all the structures is described.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900913

Reference14 articles.

1. Challenges and Rewards of Research in Marine Natural Products Chemistry in Brazil

2. Enhanced Production of Antimicrobial Compounds by Three Salt-Tolerant Actinobacterial Strains Isolated from the Sundarbans in a Niche-Mimic Bioreactor

3. One new anthraquinone from marine Streptomyces sp. FX-58

4. Bioactive metabolites of the marine actinobacterium Streptomyces sp. KMM 7210

5. Indanomycin-related antibiotics from marineStreptomyces antibioticusPTZ0016