Two New Labdane-type Diterpenes from the Wood of Cunninghamia konishii

Author:

Chang Chi-I1,Li Yen-Cheng2,Chao Che-Yi3,Wang Sheng-Yang4,Chang Hsun-Shuo5,Chao Louis Kuoping6,Yang Chang Syun7,Kuo Yueh-Hsiung78

Affiliation:

1. Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan

2. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

3. Department of Health and Nutrition Biotechnology, Asia University, Taichung 413, Taiwan

4. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan

5. Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan

6. Department of Cosmeceutics, China Medical University, Taichung 404, Taiwan

7. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

8. Department of Biotechnology, Asia University, Taichung 413, Taiwan

Abstract

Phytochemical investigation of the methanol extract of the wood of Cunninghamia konishii resulted in the isolation of two new acidic labdane-type diterpenoids, 12( S)-hydroxy-15,16-epoxylabda-8(17),13-dien-19-oic acid (1) and 12( S)-hydroxy-15,16-epoxylabda-8(17),13-dien-18-oic acid (2), along with one known labdane-type diterpene, 7,13 E-labdadien-15-ol (3). Their structures were determined by analysis of spectroscopic data and comparison with the data of known analogues.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference4 articles.

1. LiH.L., KengH. (1994) Flora of Taiwan, 2nd ed. Editorial Committee of the Flora of Taiwan, Taipei, 582–585.

2. Labdane diterpenoids from Halimium viscosum

3. Anti-tumor Promoting Diterpenes from the Stem Bark of Thuja standishii (Cupressaceae)

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