Microbial Transformation of the Diterpene 7-epi-Foliol by Fusarium fujikuroi-Reference-Cited by-同舟云学术

Microbial Transformation of the Diterpene 7-epi-Foliol by Fusarium fujikuroi

Published:2014-08 Issue:8 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Fraga Braulio M.¹,Bressa Carlo¹,González Pedro²,Guillermo Ricardo²

Affiliation:

1. Instituto de ProductosNaturales y Agrobiología, C.S.I.C., Avda. Astrofísico F. Sánchez 3, 38206-La Laguna, Tenerife, Canary Islands, Spain

2. InstitutoUniversitario de Bioorgánica “Antonio González”, Universidad de La Laguna, Tenerife, Spain

Abstract

The incubation of 3α,7α,18-trihydroxy- ent-kaur-16-ene (7- epi-foliol) with the fungus Fusarium fujikuroi gave 3α,7α,18-trihydroxy- ent-kaur-16-en-18-al as the sole product. The biotransformation of other 7α- or 7β-hydroxy derivatives had led to the oxidation of C-19, which is a main step in the biosynthesis of gibberellins and kaurenolides. Now, the presence of the 3a-hydroxyl impedes that oxidation, which is directed to the adjacent C-18 hydroxymethyl forming the corresponding aldehyde.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900802

Reference17 articles.

1. The formation of an ent-6α,7α-epoxykaurene of possible biosynthetic significance by Gibberella fujikuroi

2. The chemical and microbiological preparation of 15-oxo-gibberellin derivatives

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4. The microbiological transformation of 7α-hydroxy-ent-kaur-16-ene derivatives by Gibberella fujikuroi

5. Biotransformation of 7α-hydroxy- and 7-oxo-ent-atis-16-ene derivatives by the fungus Gibberella fujikuroi