(±)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata

Author:

Yuan Wen-Juan12,Gao Wen-Fen3,Zhang Jia-Hui4,Cao Pei4,Zhang Yu4,Chen Duo-Zhi4,Li Shun-Lin4,Di Ying-Tong4,Hao Xiao-Jiang1

Affiliation:

1. Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, P. R. China

2. University of Chinese Academy of Sciences, Beijing, 100049, P. R. China

3. Yunnan Institute for Food and Drug control, Kunming, 650201, Yunnan, P. R. China

4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, Yunnan, P. R. China

Abstract

(+)-Perforison A and (-)-perforison A, a new pair of chromone enantiomers, along with four known compounds, were isolated from the leaves and stems of Harrisonia perforata. Their structures and absolute configurations were determined on the basis of extensive analysis of spectroscopic data and electronic circular dichroism (ECD) calculations. The cytotoxic activities in vitro of these compounds were evaluated, but none showed significant activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference20 articles.

1. Hannan Institute of Botany. (1974) Hannan Flora (Hainan Zhiwu Zhi). Science, Beijing, 3, 54–55.

2. WhiteTC. (1973) Tree Flora of Malaya. Longman, London. Vol. II, 349

3. Chromones from Harrisonia perforata

4. Rearranged limonoids and chromones from Harrisonia perforata and their anti-inflammatory activity

5. Enantiomeric chromones from Harrisonia perforata

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