New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla-Reference-Cited by-同舟云学术

New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla

Published:2017-01 Issue:1 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Van Kiem Phan¹,Cuong Le Canh Viet¹,Trang Do Thi¹,Nhiem Nguyen Xuan¹,Anh Hoang Le Tuan¹,Tai Bui Huu¹,Huong Le Mai²,Van Minh Chau¹,Lee Taek Hwan³,Kim Sun Yeou⁴,Kim Seung Hyun³

Affiliation:

1. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

2. Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

3. College of Pharmacy, Yonsei Institute of Pharmaceutical Science, Yonsei University, Incheon 406–840, Korea

4. College of Pharmacy, Gachon University, Incheon 406-799, Korea

Abstract

Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPS-stimulated NO production in BV2 cells and RAW 264.7 macrophages with IC50 values of 5.4 and 8.0 μM, respectively. Compounds 1–3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC50 values ranging from 11.7 to 77.4 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200104

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