2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from Mikania guaco-Reference-Cited by-同舟云学术

2α-Acetoxy-15-acetylartemisiifolin, a new Anti-trypanosomal Sesquiterpene Lactone from Mikania guaco

Published:2017-05 Issue:5 Volume:12 Page:1934578X1701200
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Hussein Ahmed A.¹²,Romero Luz³,López-Pérez Jose Luis⁴,Gupta Mahabir P.¹

Affiliation:

1. Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 0824-00172, Panamá, Republic of Panamá

2. Chemistry Department, Cape Peninsula University of Technology, PO Box 1906, Bellville, 7535, Western Cape, South Africa

3. Universidad Santa María la Antigua and Secretaría Nacional de Ciencia, Tecnología e innovación, Panamá, Republic of Panamá

4. Department of Pharmaceutical Sciences - IBSAL-CIETUS, University of Salamanca, Avda. Campo Charro s/n, 37071 Salamanca, Spain

Abstract

Mikania guaco Bonpl. methanol extract showed an interesting activity against Trypanosoma cruzi with an IC50 of 4 μg/mL. Bioassay-guided fractionation of the methanol extract resulted in the isolation of a new sesquiterpene lactone, 2α-acetoxy, 15-acetylartemisiifolin (1), which was shown to be active (IC50 = 25 μM) against the amastigote form of T. cruzi,. The chemical structure of 1 was elucidated using 2-D NMR techniques and mass spectrometry.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1701200504

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