Design, Synthesis, and Cytotoxic Evaluation of Novel Lupane Triterpenoid Derived Hydroxamates-Reference-Cited by-同舟云学术

Design, Synthesis, and Cytotoxic Evaluation of Novel Lupane Triterpenoid Derived Hydroxamates

Published:2020-06 Issue:6 Volume:15 Page:1934578X2093196
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Tuyet Anh Dang Thi¹²,Cuc Dinh Thi¹²,Thuy Giang Le Nhat¹²,Hien Nguyen Thi³,Doan Vu Ngoc⁴,Thanh Nguyen Ha¹,Tuyen Nguyen Van¹²,Van Kiem Phan²⁵^ORCID

Affiliation:

1. Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam

2. Graduate University of Science and Technology, Cau Giay, Hanoi, Vietnam

3. Faculty of Environment, Vietnam National University of Agriculture, Vietnam

4. Le Quy Don Technical University, Cau Giay, Hanoi, Vietnam

5. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), Cau Giay, Hanoi, Vietnam

Abstract

A series of new hydroxamate derivatives of lupane triterpenoids has been designed and successfully synthesized. The synthesized compounds were evaluated for their in vitro antitumor activity using the 3-[4,5-dimethylthiazol-2-yl]−2,5-diphenyltetrazolium bromide-based assay against the human cancer cell lines KB and HepG2. Most of these derivatives possess at least moderate cytotoxic activity and the hydroxamate derivative compounds 3c, 3e, 7a, and 15b could be lead compounds for further optimization to develop novel anticancer agents.

Funder

Vietnam Academy of Science and Technology

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X20931967

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