Cucurbitane-type Triterpenes from Citrullus Lanatus (Watermelon) Seeds-Reference-Cited by-同舟云学术

Cucurbitane-type Triterpenes from Citrullus Lanatus (Watermelon) Seeds

Published:2013-10 Issue:10 Volume:8 Page:1934578X1300801
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Kikuchi Takashi¹,Okada Rina¹,Harada Yu¹,Ikushima Kenji¹,Yamakawa Takahiro¹,Yamada Takeshi¹,Tanaka Reiko¹

Affiliation:

1. Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan

Abstract

Two new cucurbitane-type triterpenes, 24-hydroperoxycucurbita-5,25-dien-3β-ol (1) and 25-hydroperoxycucurbita-5,23-dien-3β-ol (2), were isolated from a MeOH extract of Citrullus lanatus seeds. Compounds 1 and 2 exhibited moderate cytotoxic activities with IC50 values of 33.4–52.4 μM against HL-60 (human leukemia), P388 (murine leukemia), and L1210 (murine leukemia) cells. Compound 1 showed melanogenesis inhibitory activity (melanin content 80.0 %) with low cytotoxicity (cell viability 97.6 %) at a low concentration (10 μM).

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1300801006

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