Poly[3-(3,4-dihydroxyphenyl)glyceric Acid] from Anchusa italica Roots

Author:

Barbakadze Vakhtang1,Gogilashvili Lali1,Amiranashvili Lela1,Merlani Maia1,Mulkijanyan Karen1,Churadze Manana1,Salgado Antonio2,Chankvetadze Bezhan3

Affiliation:

1. I. Kutateladze Institute of Pharmacochemistry, 36 P. Sarajishvili str., 0159 Tbilisi, Georgia

2. Departamento de Química Médica, Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, 28029 Madrid, Spain

3. Department of Physical and Analytical Chemistry and Molecular Recognition and Separation Science Laboratory, School of Exact and Natural Sciences, Tbilisi State University, 3 Chavchavadze Ave., 0179 Tbilisi, Georgia

Abstract

Elucidation of the main structural unit of a water-soluble, high-molecular weight preparation from the crude polysaccharides of Anchusa italica Retz. roots has been carried out. According to 13C NMR, 1H NMR and 2D heteronuclear 1H/13C HSQC spectral data, the main structural element of the high-molecular, water-soluble preparation was a regularly substituted polyoxyethylene chain, namely poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene]. Most carboxylic groups of this caffeic acid-derived polymer of A. italica are methylated.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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