A New Coumarin and Cytotoxic Activities of Constituents from Cinnamomum cassia-Reference-Cited by-同舟云学术

A New Coumarin and Cytotoxic Activities of Constituents from Cinnamomum cassia

Published:2014-04 Issue:4 Volume:9 Page:1934578X1400900
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ngoc Tran Minh¹,Nhiem Nguyen Xuan²,Khoi Nguyen Minh¹,Son Doan Cao³,Hung Tran Viet³,Van Kiem Phan²

Affiliation:

1. National Institute of Medicinal Material, 3B Quang Trung, Hoan Kiem, Hanoi, Vietnam

2. Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Cau Giay, Hanoi, Vietnam

3. National Institute of Drug Quality Control, 48 Hai Ba Trung, Hoan Kiem, Hanoi, Vietnam

Abstract

A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and cinnamic alcohol (9), were isolated from the methanol extract of Cinnamomum cassia. Their structures were elucidated by spectral data and by comparison with the reported literature. The cytotoxic activities of compounds 1-9 were evaluated with two human cancer cell lines, HL-60 and A-549. Compound 1 showed growth inhibitory effects in the HL-60 and A-549 cell lines with IC50 values of 8.2 ± 0.5 and 11.3 ±1.1 μM, respectively. Compounds 3-6, and 8 exhibited moderate cytotoxicity with IC50 values ranging from 20.5 to 65.6 μM.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1400900414

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