Potent Acetylcholinesterase Inhibitory Compounds from Myristica fragrans

Author:

Cuong To Dao12,Hung Tran Manh1,Han Hyoung Yun3,Sik Roh Hang3,Seok Ji-Hyeon4,Lee Jong Kwon4,Jeong Ja Young4,Choi Jae Sue5,Kim Jeong Ah6,Min Byung Sun1

Affiliation:

1. College of Pharmacy, Catholic University of Daegu, Gyeongsan 712-702, Korea

2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Caugiay, Hanoi, Vietnam

3. Korea Institute of Toxicology, Deajeon 305-343, Korea

4. Korea Food & Drug Administration, Osong Health Technology Administration Complex, Chungcheongbuk-do 363-951, Korea

5. Faculty of Food Science and Biotechnology, Pukyung National University, Busan 608-73 7, Korea

6. College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 702-701 Korea

Abstract

The anti-cholinesterase activity was evaluated of the ethyl acetate fraction of the methanol extract of Myristica fragrans Houtt (Myristicaceae) seeds and of compounds isolated from it by various chromatographic techniques. The chemical structures of the compounds were determined from spectroscopic analyses (NMR data). Thirteen compounds (1—13) were isolated and identified. Compound 8 {[(7S)-8′-(4′-hydroxy-3′-methoxyphenyl)-7-hydroxypropyl]benzene-2,4-diol} showed the most effective activity with an IC50 value of 35.1 μM, followed by compounds 2 [(8R,8′S)-7′-(3′,4′-methylenedioxyphenyl)-8,8′-dimethyl-7-(3,4-dihydroxyphenyl)-butane] and 11 (malabaricone C) with IC50 values of 42.1 and 44.0 μM, respectively. This is the first report of significant anticholinesterase properties of M. fragrans seeds. The findings demonstrate that M. fragrans could be used beneficially in the treatment of Alzheimer's disease.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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