Immunological Adjuvant Activity of Pectinioside A, the Steroidal Saponin from the Starfish Patiria pectinifera-Reference-Cited by-同舟云学术

Immunological Adjuvant Activity of Pectinioside A, the Steroidal Saponin from the Starfish Patiria pectinifera

Published:2016-05 Issue:5 Volume:11 Page:1934578X1601100
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Kawase Osamu¹,Ohno Osamu²,Suenaga Kiyotake³,Xuan Xuenan⁴

Affiliation:

1. Department of Biology, Premedical Sciences, Dokkyo Medical University, 880 Kitakobayashi, Mibu-machi, Shimotsuga-gun, Tochigi 321-0293, Japan

2. Department of Chemistry and Life Science, School of Advanced Engineering, Kogakuin University, 2665–1 Nakano, Hachioji 192-0015, Japan

3. Department of Chemistry, Keio University, 3–14–1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223–8522, Japan

4. National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Nishi-2–13, Inada-cho, Obihiro, Hokkaido 080–8555, Japan

Abstract

The steroidal saponin, pectinioside A, was isolated from the starfish, Patiria pectinifera. When it was subcutaneously injected into mice with ovalbumin (OVA), it facilitated the production of OVA-specific total IgG and IgG1 but not IgG2a. To our knowledge, this is the first report suggesting that starfish saponin has the potential to be an immunological adjuvant, stimulating Th2 type immune response.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1601100511

Reference8 articles.

1. Biological activities and distribution of plant saponins

2. Advances in saponin-based adjuvants

3. Chemical Constituents and Bioactivities of Starfish

4. Starfish, Asterias amurensis and Asterina pectinifera, as Potential Sources of Th1 Immunity-Stimulating Adjuvants

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