Biological Effects of Saponin Fractions from Astragalus verrucosus in Tumor and Non-tumor Human cells-Reference-Cited by-同舟云学术

Biological Effects of Saponin Fractions from Astragalus verrucosus in Tumor and Non-tumor Human cells

Published:2018-09 Issue:9 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Facioni Maria Sole¹,Soares Joana²,Adinolfi Barabara³,Gomes Sara²,Raimundo Liliana²,Contini Adele¹,Ruffoni Barbara⁴,Azzarà Alessia¹,Tavanti Arianna¹,Bertoli Alessandra⁵,Pistelli Luisa⁵,Saraiva Lucilia²,Scarpato Roberto¹

Affiliation:

1. Dipartimento di Biologia, Unità di Genetica, University of Pisa, via Derna 1, 56126 Pisa, Italy; Research Center Nutraceuticals and Food for Health-Nutrafood, University of Pisa; Pisa, Italy

2. UCIBIO-REQUIMTE, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira 164, 4050-313 Porto, Portugal

3. Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy

4. CRA-FSO Unità di ricerca per la Floricoltura e le Specie Ornamentali, Corso Inglesi 508, 18038 Sanremo, Italy

5. Dipartimento di Farmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy; Research Center Nutraceuticals and Food for Health-Nutrafood; University of Pisa; Pisa, Italy

Abstract

Among natural chemicals used as cancer chemo-preventive and/or chemotherapeutic agents, saponins represent one of the most promising and interesting family of compounds. In this work, we aimed to elucidate the biological effects on human cells of six saponin fractions (SFs) obtained from in vitro cultures of Astragalus verrucosus Moris, a poorly characterized species. Interestingly, SF (3) showed a strongly inhibitory effect on the proliferation of human colon adenocarcinoma cell line (HCT116) via activation of a p53-dependent apoptotic pathway. In addition, SF (3) and the other SFs did not display genotoxic activity in human peripheral lymphocytes.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300903

Reference31 articles.

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2. Cancer chemoprevention through the induction of apoptosis by natural compounds

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