A New Triterpene Glucoside from Genista numidica-Reference-Cited by-同舟云学术

A New Triterpene Glucoside from Genista numidica

Published:2018-09 Issue:9 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Benayache Feryal¹²,D'Ambola Massimiliano²,Cotugno Roberta²,Chaouche Massika¹,Benayache Samir¹,Benayache Fadila¹,Braca Alessandra³,De Tommasi Nunziatina²

Affiliation:

1. Department of Chemistry, Research Unit, Development of Natural Resources, Bioactive Molecules and Physiochemical and Biological Analysis, University of Constantine 1, Algeria

2. Dipartimento di Farmacia, Università degli Studi di Salerno, via Giovanni Paolo II 132, 84084 Fisciano (SA), Italy

3. Dipartimento di Farmacia, Università di Pisa, via Bonanno 33, 56126 Pisa, Italy

Abstract

A new oleanolic acid triterpene glucoside, 3- O-β-D-glucopyranosyl-3β,21β,28-trihydroxy-olean-12-en-27-oic acid (1), has been isolated together with twelve known compounds from the chloroform and ethyl acetate extracts of Genista numidica Spach (Fabaceae) aerial parts. The structures were elucidated by spectroscopic and spectrometric analyses, mainly 1D-, 2D-NMR and MS data, and comparison with the literature. The antiproliferative activity of isolates was investigated on Jurkat, HeLa, and MCF7 cell lines. The most active triterpene, 3- O-β-D-glucopyranosyl-olean-12-en-3β,27,28,29-tetraol, showed activity in all cell lines. Further studies revealed that this compound induced in HeLa cells a cytostatic response.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300902

Reference24 articles.

1. A new alpinumisoflavone derivative from Genista pichisermolliana

2. Composition of the essential oil of Genista tricuspidata

3. Triterpene saponins of Genista ulicina Spach

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