Eco-Friendly Synthesis of Lipophilic EGCG Derivatives and Antitumor and Antioxidant Evaluation-Reference-Cited by-同舟云学术

Eco-Friendly Synthesis of Lipophilic EGCG Derivatives and Antitumor and Antioxidant Evaluation

Published:2018-09 Issue:9 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Paonessa Rosina¹,Nardi Monica²³,Di Gioia Maria Luisa⁴,Olivito Fabrizio⁵,Oliverio Manuela⁵,Procopio Antonio⁵

Affiliation:

1. Dipartimento di Medicina Sperimentale e Clinica, Università Magna Graecia di Catanzaro, Viale Europa-Campus Universitario “S. Venuta” 88100 (CZ), Italy

2. Dipartimento di Chimica, Università della Calabria, Ponte Bucci, cubo 12C, 87036 Arcavacata di Rende (CS), Italy

3. Dipartimento di Agraria, Università Telematica San Raffaele, Roma, Via di Val Cannuta, 247, 00166, Italy

4. Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Edificio Polifunzionale, Università della Calabria, 87030 Arcavacata di Rende, Cosenza, Italy

5. Dipartimento di Scienze della Salute, Università Magna Graecia, Viale Europa, Germaneto, CZ, Italy

Abstract

Epigallocatechin gallate (EGCG) was structurally modified to obtain EGCG fatty acid esters using an eco-friendly method employing Er(OTf)3 in 2-MeTHF as the catalyst. The products were purified in short times on a large scale using VERSAFLASH HTFP station on octadecyl-functionalized silica gel. The same Lewis acid showed to be a good catalyst for the synthesis of EGCG peracetated. The EGCG derivatives were assayed for their antioxidant capacity by DPPH assay and by ROS formation using the SH-SY5Y cell line.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300905

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