Affiliation:
1. Natural Product Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 607, India
Abstract
A simple and highly efficient first stereoselective total synthesis of a benzofused macrocyclic lactone, ( 3S,7R)-de- O-methylbotryosphaeriodiplodin has been accomplished utilizing Jacobson's kinetic resolution, Marouka asymmetric allylation, Stille coupling, and ring-closing metathesis (RCM) reactions as key steps.
Subject
Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine