New Abietane-type Diterpenoids from the Bark of Cryptomeria japonica

Author:

Chang Chi-I1,Cheng Jih-Jung23,Hsu Chin4,Chen Cheng-Chi5,Cheng Wei-Yi6,Wang Sheng-Yang78,Lee Ching-Kuo9,Cheng Ming-Jen10,Kuo Yueh-Hsiung111213

Affiliation:

1. Department of Biological Science and Technology, National Pingtung University of Science and Technology, Pingtung 912, Taiwan

2. Faculty of Pharmacy, School of Pharmaceutical Sciences, National Yang-Ming University, 112, Taipei, Taiwan

3. Department of Medical Research, China Medical University, Taichung 404, Taiwan

4. Department of Exercise Health Science, National Taiwan University of Physical Education and Sport, Taichung 404, Taiwan

5. Department of Chemistry, National Taiwan University, Taipei 106, Taiwan

6. Department of Medical Nutrition, I-shou University, Kaoshiung 824, Taiwan

7. Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan

8. Agricultural Biotechnology Research Center, Academia Sinica, Taipei 115, Taiwan

9. Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei 110, Taiwan

10. Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), 300, Hsinchu, Taiwan

11. Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 404, Taiwan

12. Department of Biotechnology, Asia University, Taichung 413, Taiwan

13. Chinese Medicine Research Center, China Medical University, Taichung 404, Taiwan

Abstract

Two new abietane-type diterpenoids, 15-hydroxy-12- O-methylsugiol (1) and 2a-hydroxy-12- O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Reference39 articles.

1. GanWS. (1958) Manual of Medicine Plants in Taiwan, Vol 1, National Research Institute of Chinese Medicine, Taipei, 54.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3