Cembranoids From the Leaves of <i>Nicotiana tabacum</i> and Their Neuroprotective Activities-Reference-Cited by-同舟云学术

Cembranoids From the Leaves of Nicotiana tabacum and Their Neuroprotective Activities

Published:2022-04 Issue:4 Volume:17 Page:1934578X2210941
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Yang Peng-fei¹^ORCID,Chen Mei-yu¹,Yu Jian-chun²,Yang Jing¹,Wang Qiong-bo³,Mao Duo-bin¹

Affiliation:

1. College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou, China

2. Technology Center, China Tobacco Henan Industrial Co., Ltd, Zhengzhou, China

3. Luohe Medical College, Luohe, China

Abstract

A new cembrane-type diterpenoid (1) and 9 known cembranoids (2-10) were isolated from the leaves of Nicotiana tabacum. The structure of the new metabolite was confirmed by extensive analyses of their spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), 1D- and 2D nuclear magnetic resonance (NMR) spectroscopy, and infrared spectroscopy (IR). All of the isolated compounds were tested for their protective effects against oxygen-glucose deprivation (OGD)-induced neurotoxicity in SH-SY5Y cells. The new compound 1 exhibited a moderate protective effect against OGD-induced neurotoxicity at 10 μM.

Funder

National Natural Science Foundation of China

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X221094107

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2. Cembranoids from the Gum Resin of Boswellia carterii as Potential Antiulcerative Colitis Agents

3. Nicotabaflavonoidglycoside, the first example of cembranoid and flavonoid heterodimer from Nicotiana tabacum

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