Characterization of Cytochalasins and Steroids From the Ascomycete Daldinia concentrica and Their Cytotoxicity-Reference-Cited by-同舟云学术

Characterization of Cytochalasins and Steroids From the Ascomycete Daldinia concentrica and Their Cytotoxicity

Published:2019-05 Issue:5 Volume:14 Page:1934578X1984632
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Trung Hoang Van¹,Kuo Ping-Chung²,Tuan Nguyen Ngoc³,Ngan Nguyen Thi³,Trung Nguyen Quang⁴,Thanh Nguyen Tan¹,Hai Ha Viet⁵,Phuong Doan Lan⁵,Giang Bach Long⁶,Li Yue-Chiun⁷,Wu Tian-Shung²⁸,Thang Tran Dinh¹

Affiliation:

1. School of Chemistry, Biology and Environment, Vinh University, Vietnam

2. School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan

3. Institute of Biotechnology and Food Technology, Industrial University of Ho Chi Minh City, Vietnam

4. Nghean Oncology Hospital, Vinh City, Vietnam

5. Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

6. NTT Institute of High Technology, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

7. Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung

8. Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung

Abstract

One new cytochalasin daldinin (1), 2 known cytochalasins 2 and 3, along with 2 steroids 4 and 5, were characterized from the methanol extracts of the fruiting bodies of Daldinia concentrica. The structure of new compound 1 was elucidated using a combination of 1- and 2-dimensional nuclear magnetic resonance spectroscopic and high-resolution electrospray ionization mass spectrometric analyses. In addition, the isolated compounds were examined for their cytotoxicity against several tumor cell lines and the tested compounds demonstrated moderate-to-weak cytotoxicity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X19846320

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