A Cytotoxic Diterpenoid from Croton Membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana-Reference-Cited by-同舟云学术

A Cytotoxic Diterpenoid from Croton Membranaceus, the Major Constituent of Anticancer Herbal Formulations Used in Ghana

Published:2008-11 Issue:11 Volume:3 Page:1934578X0800301
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Bayor Marcel T.¹,Ayim John S. K.¹,Marston Gemma²,Phillips Roger M.²,Shnyder Steven D.²,Wheelhouse Richard T.³,Wright Colin W.¹

Affiliation:

1. Faculty of Pharmacy, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana

2. Institute of Cancer Therapeutics, University of Bradford, West Yorkshire, BD7 1DP, UK

3. Bradford School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK

Abstract

Croton membranaceus is used by herbalists and traditional healers in Ghana for the management of various cancers, especially prostate cancers. A methanolic extract of the roots showed cytotoxic activities against two cancer cell lines, and bioassay-guided fractionation of this extract revealed that the cytotoxic activity resided mostly in the ethyl acetate fraction. Six compounds were isolated from this fraction, including a new furano-clerodane diterpenoid (1), for which the trivial name crotomembranafuran is suggested. This compound exhibited an IC50 value of 4.1 μg/mL (10.6 μM) against human prostate (PC-3) cells, providing some support for the traditional use of C. membranaceus in the treatment of cancers.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X0800301116

Reference12 articles.

1. Clerodane diterpenes of Croton hovarum

2. Diterpenoids from the stem bark of Croton zambesicus

3. 6,7-Oxygenated neo-clerodane furan diterpenes from Croton sonderianus

4. Three clerodane diterpenoids from Croton eluteria Bennett

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