Secondary Metabolites From the Grasshopper-Derived Entomopathogenic Fungus Aspergillus Tamarii NL3 and Their Biological Activities

Author:

Ton That Huu Dat1ORCID,Phuong Ha Tran1,Diem Tran Phan Thi1,Souvannalath Bakeo2,Trung Hieu Le3,Ho Duc Viet4,Viet Cuong Le Canh1ORCID

Affiliation:

1. Mientrung Institute for Scientific Research, Vietnam National Museum of Nature, Vietnam Academy of Science and Technology (VAST), Thua Thien Hue, Vietnam

2. Center for Biotechnology and Ecology, Ministry of Agriculture and Forestry - Laos, Vientiane, Laos

3. Hue University of Sciences, Hue University, Thua Thien Hue, Vietnam

4. Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, Thua Thien Hue, Vietnam

Abstract

Chromatographic purification of the ethyl acetate extract of the entomopathogenic fungus Aspergillus tamarii NL3 culture broth led to the isolation of griseofulvin (1), isogriseofulvin (2), cytochalasin J (3), solamargine (4), and solasonine (5). The chemical structures of these compounds were identified by HRESIMS and NMR spectra, as well as by comparison with literature data. This is the first report on the isolation of 1-4 from the Aspergillus genus and compound 5 from A tamarii. Compounds 1 and 2 exhibited antifungal activity against the reference fungi with MICs of 16 to 128 µg/mL. Compound 3 displayed weak antimicrobial activity against most of the tested microorganisms with MICs ≥ 128 µg/mL, except for Bacillus subtilis and Aspergillus niger with MICs of 64 µg/mL. Compounds 4 and 5 showed activity against a wide spectrum of the reference microorganisms with MICs of 16 to 128 µg/mL but showed stronger antifungal than antibacterial activity. Furthermore, all isolates exhibited weak ABTS and DPPH scavenging activities with scavenging rates of 18.92% to 32.64% and 24.62% to 31.06%, respectively, at the concentration of 100 µg/mL.

Funder

Vietnam Academy of Science and Technology

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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