Anti-HIV 1 Activity of Xanthones from the Bark of Mammea harmandii-Reference-Cited by-同舟云学术

Anti-HIV 1 Activity of Xanthones from the Bark of Mammea harmandii

Published:2018-01 Issue:1 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Liangsakul Ponsiri¹²,Kuhakarn Chutima¹,Hongthong Sakchai¹,Jariyawat Surawat³,Suksen Kanoknetr³,Akkarawongsapat Radeekorn⁴,Limthongkul Jitra⁴,Napaswad Chanita⁴,Reutrakul Vichai¹

Affiliation:

1. Department of Chemistry, and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

2. Department of Agronomy, Faculty of Agriculture at Kamphaeng Saen, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand

3. Department of Physiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

4. Department of Microbiology, Faculty of Science, Mahidol University, Rama 6 Road, Bangkok 10400, Thailand

Abstract

A new xanthone glycoside 1 together with four known flavonoid derivatives, astilbin (2), neoastilbin (3), isoastilbin (4), and epicatechin (5) were isolated from the ethyl acetate fraction partitioned from the methanol extract of the bark of Mammea harmandii. The chemical structures of all isolated compounds were established on the basis of their spectroscopic data. Compound 1 exhibited selective significant inhibitory activity in the anti-syncytium assay with an EC50 value of 11.44 μM (SI = 14.03) while it was found inactive against HIV 1 reverse transcriptase as well as cytotoxic activity.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300116

Reference18 articles.

1. Variability of traits and bioactive compounds in the fruit and pulp of six mamey apple ( Mammea americana L.) accessions

2. Antioxidant activity of Mammea longifolia bud extracts

3. Pyranocoumarins from the twigs of Mammea siamensis

4. Cytotoxicity and inhibition of P-glycoprotein by selected medicinal plants from Thailand

5. Cytotoxic Coumarins from the Bark of Mammea siamensis

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