Cytotoxicity against Cholangiocarcinoma and HepG2 Cell Lines of Lignans from Hernandia nymphaeifolia-Reference-Cited by-同舟云学术

Cytotoxicity against Cholangiocarcinoma and HepG2 Cell Lines of Lignans from Hernandia nymphaeifolia

Published:2018-01 Issue:1 Volume:13 Page:1934578X1801300
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Suthiwong Jittra¹,Boonloh Kampeebhorn²,Kukongviriyapan Veerapol²,Yenjai Chavi¹

Affiliation:

1. Natural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand

2. Department of Pharmacology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

Abstract

Eleven lignans (1-11) were isolated from the seed of Hernandia nymphaeifolia. Most of the lignans exhibited strong to moderate cytotoxicity against cholangiocarcinoma KKU-M156 and HepG2 cell lines. Compounds 4 and 8 showed cytotoxicity against the KKU-M156 cell line with IC50 values of 5.2 μ M (Emax 96%) and 5.4 (Emax 59%) μM, respectively. In the cases of cytotoxicity against the HepG2 cell line, compounds 2, 3, 4, and 8 showed cytotoxicity with IC50 values of 1.7 M (Emax 84%), 4.1 μM (Emax 74%), 4.5 μM (Emax 68%), and 5.2 μM (Emax 78%), respectively.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1801300118

Reference26 articles.

1. New Oxoaporphine Alkaloids from Hernandia nymphaeifolia

2. Cytotoxic lignans from formosan Hernandia nymphaeifolia

3. Anti-Platelet Aggregation Alkaloids and Lignans from Hernandia nymphaeifolia

4. Lignans from leaves of Juniperus chinensis