Chromolithic Method Development, Validation and System Suitability Analysis of Ultra-Sound Assisted Extraction of Glycyrrhizic Acid and Glycyrrhetinic Acid from Glycyrrhiza glabra

Author:

Gupta Suphla1,Sharma Rajni2,Pandotra Pankaj1,Jaglan Sundeep1,Gupta Ajai Prakash3

Affiliation:

1. Plant Biotechnology Division, Jammu-180001, Jammu & Kashmir, India

2. Natural Product Division, Jammu-180001, Jammu & Kashmir, India

3. Patent Cell Division, Indian Institute of Integrative Medicine, Jammu-180001, Jammu & Kashmir, India

Abstract

An ultrasound-assisted extraction and chromolithic LC method was developed for simultaneous determination of glycyrrhizic acid (GA) and glycyrrhetinic acid (GL) from the root extract of Glycyrrhiza glabra using RPLC-PDA. The developed method was validated according to the International Conference on Harmonisation. The method exhibited good linearity (r2 >0.9989) with high precision and achieved good accuracies between 97.5 to 101.3% of quantitative results. The method is more sensitive and faster (resolved within ten minutes) than the earlier developed methods using normal LC columns.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

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