The Cytotoxic Activity of Diterpenoids from Isodon species-Reference-Cited by-同舟云学术

The Cytotoxic Activity of Diterpenoids from Isodon species

Published:2012-08 Issue:8 Volume:7 Page:1934578X1200700
ISSN:1934-578X
Container-title:Natural Product Communications
language:en
Short-container-title:Natural Product Communications

Author:

Ohsaki Ayumi¹,Ozawa Masaaki¹,Komiyama Kanki²,Kishida Akio¹,Isobe Takahiko³

Affiliation:

1. Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University 2-3-10, Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan

2. Kitasato Research Center for Environmental Science, 1-15-1, Kitasato, Minami-ku, Sagamihara 252-0329, Japan

3. Department of Chemistry, General Education Center, Hyogo University of Health Sciences 1-3-6, Minatojima, Chuo-ku, Kobe 650-8530, Japan

Abstract

Fifteen Isodon diterpenoids (1–15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.

Publisher

SAGE Publications

Subject

Complementary and alternative medicine,Plant Science,Drug Discovery,Pharmacology,General Medicine

Link

http://journals.sagepub.com/doi/pdf/10.1177/1934578X1200700803

Reference8 articles.

1. The Study on the Antibacterial Activity of Compounds from the Isodon Species

2. SunH.D., XuY.L., JiangB. (2001) Diterpenoids from Isodon species. Science Press, Beijing, 1–388.

3. Diterpenoids from Isodon species and their biological activities